Date of Award

12-2014

Degree Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Chemistry and Biochemistry

Committee Chair

Karl J. Wallace

Committee Chair Department

Chemistry and Biochemistry

Committee Member 2

Douglas Masterson

Committee Member 2 Department

Chemistry and Biochemistry

Committee Member 3

Wujian Miao

Committee Member 3 Department

Chemistry and Biochemistry

Committee Member 4

Vijay Rangachari

Committee Member 4 Department

Chemistry and Biochemistry

Committee Member 5

Matthew Donahue

Committee Member 5 Department

Chemistry and Biochemistry

Abstract

A number of molecular probes have been designed and synthesized for the detection of Zn2+ and Fe3+ ions. Two types of functional groups have been incorporated into the molecular scaffolds to utilize different fluorescent mechanisms. The first class of receptors contains a pyrene moiety. These molecular probes use the excimer mechanism for the detection of Zn2+ ion. The probes work well in an organic solvent with a detection limit of 20 nM (one ppb). Alternatives are made to make them water soluble, but this proved to be difficult. An interesting ion-induced self-assembly system will also be discussed.

The second class of molecules is based on the “Off-On” mechanism. The rhodamine dyes are used in these molecular probes. This system is found to be selective for Fe3+ ions in a mixed organic/aqueous system. A protocol has also been developed to distinguish between Fe3+ and Al3+ ions. One of the rhodamine dyes has also been shown to detect Fe3+ ion in bacteria.

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