A new and efficient synthetic route for the synthesis of 3,6-dimethylpyrazine-2,5-dicarboxylic acid hydrate: molecular structure and unique supramolecular interactions

Shawna Balof, University of Southern Mississippi
LaMaryet Moody, University of Southern Mississippi
Alvin A. Holder, University of Southern Mississippi

Abstract

The regioselective oxidation of 2,3,5,6,-tetramethyl pyrazine by selenium dioxide and silver nitrate resulted in the production of, 3,6-dimethylpyrazine-2,5-dicarboxylic acid hydrate in high yields. Its crystal structure, which is reported for the very first time, consists of a unique infinite three-dimensional lattice of hydrogen-bonded acid and water molecules.