Title

Synthesis of New Polyfunctional 2-Pyrrolidinones from Methyl 2-(carboethoxyhydroxymethyl)Acrylate

Document Type

Article

Publication Date

7-30-2007

Department

Chemistry and Biochemistry

Abstract

The synthesis of new polyfunctional 2-pyrrolidinone derivatives from methyl 2-(carboethoxyhydroxymethyl)acrylate is described. These alkenes present an extremely high reactivity upon Michael addition with primary amines leading to a simple, mild, and efficient route to the preparation of new polyfunctional pyrrolidinones. (C) 2007 Elsevier Ltd. All rights reserved.

Publication Title

Tetrahedron Letters

Volume

48

Issue

31

First Page

5555

Last Page

5559