Stimuli-Responsive Peptide-Based ABA-Triblock Copolymers: Unique Morphology Transitions With pH
Polymers and High Performance Materials
We report the synthesis and solution characterization of poly(L-lysine)-b-poly(propylene oxide)-b-poly(L-lysine) (KPK) triblock copolymers with high lysine weight fractions (>75 wt%). In contrast to PK diblock copolymers in this composition range, KPK triblock copolymers exhibit morphology transitions as a function of pH. Using a combination of light-scattering and microscopy techniques, we demonstrate spherical micelle-vesicle and spherical micelle-disk micelle transitions for different K fractions. We interpret these morphology changes in terms of the energy penalty associated with folding the core P block to form a spherical micelle in relation to the interfacial curvature associated with different charged states of the K block.
Macromolecular Rapid Communications
Ray, J. G.,
Naik, S. S.,
Hoff, E. A.,
Johnson, A. J.,
Ly, J. T.,
Easterling, C. P.,
Patton, D. L.,
Savin, D. A.
(2012). Stimuli-Responsive Peptide-Based ABA-Triblock Copolymers: Unique Morphology Transitions With pH. Macromolecular Rapid Communications, 33(9), 819-826.
Available at: http://aquila.usm.edu/fac_pubs/252