Title

Direct, Controlled Synthesis of the Nonimmunogenic, Hydrophilic Polymer, Poly(N-(2-hydroxypropyl)Methacrylamide) via RAFT in Aqueous Media

Document Type

Article

Publication Date

7-1-2005

Department

Polymers and High Performance Materials

Abstract

Poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) is a nonimmunogenic, neutral-hydrophilic polymer currently employed in the delivery of anticancer drugs. Herein, we report conditions that facilitate the direct, controlled RAFT polymerization of HPMA in aqueous media. We demonstrate that the use of 4-cyano-pentanoic acid dithiobenzoate and 4,4'-azobis(4-cyanopentanoic acid) as the chain transfer agent (CTA) and initiating species, respectively, in the presence of an acetic acid buffer solution at 70 degrees C is a suitable condition leading to controlled polymerization. The "living" nature of these polymerizations is demonstrated via chain-extension of an HPMA macro CTA to yield the corresponding poly(HPMA-b-HPMA) "homopolymer".

Publication Title

Biomacromolecules

Volume

6

Issue

4

First Page

1846

Last Page

1850