Release and Formation of Surface-Localized Ionic Clusters (SLICs) Into Phospholipid Rafts From Colloidal Solutions During Coalescence
Polymers and High Performance Materials
Stimuli-responsive behavior of phospholipids in the presence of ionic surfactants utilized in synthesis of MMA/nBA colloidal particles was investigated. Utilizing 1-myristoyl-2-hydroxy-sn-glycero-phosphocholine (MHPC) phospholipid, and sodium dioctyl sulfosuccinate (SDOSS) surfactant as dispersing media in H2O, narrow unimodal particle size distributions of methyl methacrylate (MMA)/n-butylacrylate (nBA) copolymers were synthesized. The particle diameters were 154 nm when a SDOSS/MHPC mixture was used and 161 nm using MHPC as the only surface-stabilizing species. When such colloidal dispersions are exposed to 1.7, 3.3, and 6.7 mM aqueous CaCl2 and KCl electrolyte solutions, surface-localized ionic clusters are generated at the film-air interface that may serve as lipid rafts composed of crystalline phases of MHPC deposited on poly(MMA)/nBA films. These studies illustrate that it is possible to control release and morphology developments of surface phospholipid rafts on artificial surfaces.
Lestage, D. J.,
Urban, M. W.
(2005). Release and Formation of Surface-Localized Ionic Clusters (SLICs) Into Phospholipid Rafts From Colloidal Solutions During Coalescence. Langmuir, 21(6), 2150-2157.
Available at: http://aquila.usm.edu/fac_pubs/2809