Title

THE DROSOPHILA-TUMOROUS-LETHAL HEMATOPOIETIC ONCOGENE IS A DOMINANT MUTATION IN THE HOPSCOTCH LOCUS

Document Type

Article

Publication Date

4-1-1993

Department

Biological Sciences

Abstract

The Drosophila Tumorous-lethal (Tum-l) mutation acts as an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation. Tum-l is a dominant mutation in the hopscotch (hop) locus, which is required for cell division and for proper embryonic segmentation. The Tum-l temperature-sensitive period for melanotic tumor formation includes most of larval and pupal development.

Publication Title

MOLECULAR & GENERAL GENETICS

Volume

238

Issue

41276

First Page

33

Last Page

37

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