A new and efficient synthetic route for the synthesis of 3,6-dimethylpyrazine-2,5-dicarboxylic acid hydrate: molecular structure and unique supramolecular interactions

Shawna Balof, University of Southern Mississippi
LaMaryet Moody, University of Southern Mississippi
Alvin A. Holder, University of Southern Mississippi


The regioselective oxidation of 2,3,5,6,-tetramethyl pyrazine by selenium dioxide and silver nitrate resulted in the production of, 3,6-dimethylpyrazine-2,5-dicarboxylic acid hydrate in high yields. Its crystal structure, which is reported for the very first time, consists of a unique infinite three-dimensional lattice of hydrogen-bonded acid and water molecules.