The synthesis of a fully degradable, bio-based, sustained release, pro-antimicrobial polymer network comprised of degradable acetals (PANDA) is reported. The active antimicrobial agent – p-anisaldehyde (pA) (an extract from star anise) – was converted into a UV curable acetal containing pro-antimicrobial monomer and subsequently photopolymerized into a homogenous thiol-ene network. Under neutral to acidic conditions (pH < 8), the PANDAs undergo surface erosion and exhibit sustained release of pA over 38 days. The release of pA from PANDAs was shown to be effective against both bacterial and fungal pathogens. From a combination of confocal microscopy and transmission electron microscopy, we observed that the released pA disrupts the cell membrane. Additionally, we demonstrated that PANDAs have minimal cytotoxicity towards both epithelial cells and macrophages. Although a model platform, these results point to promising pathways for the design of fully degradable sustained-release antimicrobial systems with potential applications in agriculture, pharmaceuticals, cosmetics, household/personal care, and food industries.
Amato, D. V.,
Amato, D. N.,
Blancett, L. T.,
Mavrodi, O. V.,
Martin, W. B.,
Swilley, S. N.,
Sandoz, M. J.,
Mavrodi, D. V.,
(2018). A Bio-Based Pro-Antimicrobial Polymer Network Via Degradable Acetal Linkages. Acta Biomaterialia, 67, 196-205.
Available at: https://aquila.usm.edu/fac_pubs/15049
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