Title

Highly Potent Anti-Proliferative Effects of a Gallium (III) Complex With 7-Chloroquinoline Thiosemicarbazone as a Ligand: Synthesis, Cytotoxic and Antimalarial Evaluation

Document Type

Article

Publication Date

10-30-2014

Department

Biological Sciences

Abstract

A gallium(III) complex with 7-chloroquinoline thiosemicarbazone was synthesized and characterized. The complex proved to be thirty-one times more potent on colon cancer cell line, HCT-116, with considerably less cytotoxicity on non-cancerous colon fibroblast, CCD-18Co, when compared to etoposide. Its anti-malarial potential on 3D7 isolate of Plasmodium falciparum was better than lumefantrine.

Publication Title

European Journal of Medicinal Chemistry

Volume

86

First Page

81

Last Page

86

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