Document Type

Article

Publication Date

11-9-2016

Department

Biological Sciences

Abstract

Streptococcus pneumoniae is one of the leading causes of community acquired pneumonia and acute otitis media. Certain aspects of S. pneumoniae’s virulence are dependent upon expression and release of the protein toxin pneumolysin (PLY) and upon the activity of the peroxide-producing enzyme, pyruvate oxidase (SpxB). We investigated the possible synergy of these two proteins and identified that release of PLY is enhanced by expression of SpxB prior to stationary phase growth.

Publication Title

BMC Microbiology

Volume

16

Issue

271

Included in

Biology Commons

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