Title

PKC-Dependent Phosphorylation of Munc18a at Ser313 in Activated RBL-2H3 Cells

Document Type

Article

Publication Date

1-2018

Department

Biological Sciences

Abstract

Protein Kinase C (PKC) regulates the release of pro-inflammatory compounds from IgE/antigen-activated mast cells by unknown mechanisms. In this study, we show for the first time that PKC inhibitor Ro-03-0432, which inhibits RBL-2H3 exocytosis/degranulation in a concentration-dependent fashion, prevents the phosphorylation of membrane fusion factor Munc18a at Ser 313. Our study provides fresh evidence that PKC-dependent protein phosphorylation may contribute to the intricate regulation of mast cell degranulation by directly targeting the fusion factors.

Publication Title

Inflammation Research

Volume

67

Issue

1

First Page

1

Last Page

3

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