Thiol-ene Click Post-Polymerization Modification of a Fluorescent Conjugated Polymer for Parts-Per-Billion Pyrophosphate Detection in Seawater
Polymers and High Performance Materials
The evolution of conjugated polyelectrolytes (CPEs) that transduce analyte-receptor interactions into detectable fluorescent responses in complex aqueous environments is predicated on advancements in molecular design and improved synthetic accessibility. Here, we demonstrate a simple post-polymerization modification protocol based on thiol-ene click chemistry that results in the rapid installation of sodium sulfate terminated side chains to a poly(fluorene-co-ethynyl) scaffold. The fluorescence of the resulting water-soluble CPE is quenched by Fe3+, dequenched selectively by pyrophosphate (PPi), and accurately quantifies PPi within ±6 nM in artificial seawater. The broad utility of thiol-ene click chemistry should offer the straightforward integration of diverse sensing elements.
ACS: Applied Polymer Materials
Williams, A. K.,
Crater, E. R.,
Azoulay, J. D.
(2019). Thiol-ene Click Post-Polymerization Modification of a Fluorescent Conjugated Polymer for Parts-Per-Billion Pyrophosphate Detection in Seawater. ACS: Applied Polymer Materials.
Available at: https://aquila.usm.edu/fac_pubs/15852