Rational Design of Biopolymers via Aqueous Reversible Addition-Fragmentation Chain Transfer Polymerization

Stacey E. York, University of Southern Mississippi
Adam W. York, University of Southern Mississippi
Charles L. McCormick, University of Southern Mississippi


Over the last decade significant advances in reversible addition-fragmentation chain transfer (RAFT) polymerization have lead to increased opportunities for the tailored design of polymers in the biomedical field. The ensuing discussion provides examples of rationally designed polymers for biomedical applications. Specifically, the synthesis and characterization of responsive shell cross-linked micelles, actively-targeted gene carriers, and temperature-responsive gels are described.