Adsorption/Desorption Processes of pH-Responsive Copolymers On Model Dental Surfaces via QCM and AFM Analysis

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Polymers and High Performance Materials


The stimuli-responsive adsorption of polyelectrolytes to biosurfaces provides an important vehicle for development of protective coatings, delivery of therapeutic agents, and cosmetic applications. Developing a fundamental understanding of the mechanisms and kinetics of adsorption/desorption processes of polymeric systems to biological surfaces is of critical importance in predicting performance and designing new formulations. This study describes quartz crystal microbalance and atomic force microscopy analysis of a poly(methyl vinyl ether-alt-maleic anhydride) copolymer (Gantrez® S97 BF) adsorption on dental mimicking surfaces to determine properties including thickness, morphology, viscoelasticy, and rate of adsorption/desorption of the polymer layer as a function of solution environment. A nanoscopically smooth model dental surface was developed for AFM analysis of the adsorbed thin film. It was found that solution pH, salinity, and polymer concentration affected the adsorption process and morphology of the adsorbed polymer layer. A higher rate of adsorption, greater stability, and a more homogeneous deposited film were observed for solutions with pH 4 than for those with pH 7, which was attributed to the charge state of polymer and substrate at the solution pH. Dramatic changes in polymer adsorption and film properties were observed as a function of polymer concentration with respect to the critical overlap concentration.

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ACS Symposium Series



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