Tick saliva facilitates tick feeding and infection of the host. Gene expression analysis of tick salivary glands and other tissues involved in host-pathogen interactions has revealed a wide range of bioactive tick proteins. Transcriptomic analysis has been a milestone in the field and has recently been enhanced by next-generation sequencing (NGS). Furthermore, the application of quantitative proteomics to ticks with unknown genomes has provided deeper insights into the molecular mechanisms underlying tick hematophagy, pathogen transmission, and tick-host-pathogen interactions. We review current knowledge on the transcriptomics and proteomics of tick tissues from a systems-biology perspective and discuss future challenges in the field.
Trends in Parasitology
Francischetti, I. M.,
Pedra, J. H.,
(2016). Sialomes and Mialomes: A Systems-Biology View of Tick Tissues and Tick-Host Interactions. Trends in Parasitology, 32(3), 242-254.
Available at: https://aquila.usm.edu/fac_pubs/17537