Document Type

Article

Publication Date

3-2016

Department

Biological Sciences

Abstract

Tick saliva facilitates tick feeding and infection of the host. Gene expression analysis of tick salivary glands and other tissues involved in host-pathogen interactions has revealed a wide range of bioactive tick proteins. Transcriptomic analysis has been a milestone in the field and has recently been enhanced by next-generation sequencing (NGS). Furthermore, the application of quantitative proteomics to ticks with unknown genomes has provided deeper insights into the molecular mechanisms underlying tick hematophagy, pathogen transmission, and tick-host-pathogen interactions. We review current knowledge on the transcriptomics and proteomics of tick tissues from a systems-biology perspective and discuss future challenges in the field.

Comments

Accepted version available through a CC BY-NC-ND license. The final, published version is available from the publisher's website: https://doi.org/10.1016/j.pt.2015.10.002

Publication Title

Trends in Parasitology

Volume

32

Issue

3

First Page

242

Last Page

254

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