Title

Influence of Aerobic Fitness on Vasoreactivity in Young Men

Document Type

Article

Publication Date

10-2017

Department

Kinesiology

Abstract

Previous work has demonstrated a direct relationship between aerobic fitness and vasodilatory function (i.e., flow-mediated dilation; FMD); however, the relation between aerobic fitness and vasoconstrictor responsiveness (i.e., low flow-mediated constriction; L-FMC), and the overall vasoactive range (FMD + L-FMC) is unclear. Purpose To test the hypothesis that L-FMC and the overall vasoactive range (FMD + L-FMC) will be related to aerobic fitness in young, healthy men. Methods Twenty men (age: 23 +/- 5 years) were recruited, and divided evenly into a higher (HF) vs. lower (LF) aerobic fitness group, quantified via YMCA cycle ergometry (VO2 peak extrapolation), and a 3-min step test (1-min heart rate recovery). Duplex Doppler-ultrasound was used to assess brachial artery FMD and L-FMC. Results Estimated VO2 peak (HF = 55 +/- 10 vs. LF = 38 +/- 5 mL/kg/min) and heart rate recovery (HF = 36 +/- 10 vs. LF = 25 +/- 8 beats) were greater in the HF group (P < 0.05). FMD and the vasoactive range were similar between groups; however, L-FMC was significantly greater in HF (HF = -2.5 +/- 1.6 vs. LF = -0.7 +/- 1.8%, P < 0.05; d = 1.18). A correlational analysis revealed an inverse relationship between L-FMC and both HR recovery (r = -0.665, P < 0.01) and estimated VO2 peak (r = -0.5, P < 0.05). Conclusions This work supports an association between L-FMC and aerobic fitness in young, healthy men. Longitudinal or interventional studies are warranted to support causality, and to distinguish whether L-FMC is more sensitive to changes in aerobic fitness than FMD.

Publication Title

European Journal of Applied Physiology

Volume

117

Issue

10

First Page

2075

Last Page

2083

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