Synthesis of New Polyfunctional 2-pyrrolidinones From Methyl 2-(carboethoxyhydroxymethyl)acrylate

Jean-François Morizur
Lon J. Mathias, University of Southern Mississippi


The synthesis of new polyfunctional 2-pyrrolidinone derivatives from methyl 2-(carboethoxyhydroxymethyl)acrylate is described. These alkenes present an extremely high reactivity upon Michael addition with primary amines leading to a simple, mild, and efficient route to the preparation of new polyfunctional pyrrolidinones. (C) 2007 Elsevier Ltd. All rights reserved.