An integrated web-based model for management, analysis and retrieval of EST biological information

YP Deng
YH Dong
SJ Brown
CY Zhang


In this work, an integrated Web-based model integrating a number of components has been proposed to analyze, manage and retrieve biological information. In particular, we deal with Expressed Sequence Tags (EST) data that is an important resource for gene identification, genome annotation and comparative genomics. A high-performance and user-friendly three-tier Web application consisting of EST modeling and database (ESTMD) has been developed to facilitate the retrieval and analysis of EST information. It provides a variety of Web services and tools for searching raw, cleaned and assembled EST sequences, genes and Gene Ontology, as well as pathway information. It can be accessed at