Synthesis of New Polyfunctional 2-pyrrolidinones from Methyl 2-(carboethoxyhydroxymethyl)acrylate

Lon J. Mathias, University of Southern Mississippi

Originally published in Tetrahedron Letters
Volume 48, Issue 31, 30 July 2007, Pages 5555-5559

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The synthesis of new polyfunctional 2-pyrrolidinone derivatives from methyl 2-(carboethoxyhydroxymethyl)acrylate is described. These alkenes present an extremely high reactivity upon Michael addition with primary amines leading to a simple, mild, and efficient route to the preparation of new polyfunctional pyrrolidinones. © 2007 Elsevier Ltd. All rights reserved.