Title

The Utility of the T-maze in Assessing Learning, Memory, and Models of Neurological Disorders in the Zebrafish

Document Type

Article

Publication Date

2012

Department

Psychology

Abstract

The field of zebrafish research has a firm foundation in the realm of genetics and developmental biology. The volume of research in this area, coupled with concerted efforts at replication and validation of the findings have effectively established the zebrafish model as an important one within these fields. A host of studies have expanded the utility of this model into the fields of neuroscience, cognition, and behavior (broadly defined). With the recent sequencing of the genome, along with the ease and availability of genetic mutant models, the opportunity exists to expand upon the knowledge of the genetic origins and the influencing factors of genes on neurobehavioral components, most notably, learning and memory. Biochemical, histological, neurological, and anatomical data suggest that zebrafish are a viable model of human disease states and a solid candidate for the screening of pharmacotherapies. In order to effectively assess the effects of experimentally administered drugs, it is imperative that we have a thorough baseline understanding of zebrafish behavior and performance on learning and memory tasks. Not only must these tests be developed, but they must also be empirically assessed and found to be both reliable and valid. To this end, zebralish researchers have implemented the use of the T-maze.

Publication Title

Behaviour

Volume

149

Issue

10-12

First Page

1081

Last Page

1097