The Drosophila-Tumorous-Lethal Hematopoietc Oncogene is a Dominant Mutation in Hopscotch Locus
The Drosophila Tumorous-lethal (Tum-l) mutation acts as an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation. Tum-l is a dominant mutation in the hopscotch (hop) locus, which is required for cell division and for proper embryonic segmentation. The Tum-l temperature-sensitive period for melanotic tumor formation includes most of larval and pupal development.
Molecular and General Genetics
Hanratty, W. P.,
Dearolf, C. R.
(1993). The Drosophila-Tumorous-Lethal Hematopoietc Oncogene is a Dominant Mutation in Hopscotch Locus. Molecular and General Genetics, 238(41276), 33-37.
Available at: http://aquila.usm.edu/fac_pubs/8743