Date of Award
12-2014
Degree Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Chemistry and Biochemistry
Committee Chair
Karl J. Wallace
Committee Chair Department
Chemistry and Biochemistry
Committee Member 2
Douglas Masterson
Committee Member 2 Department
Chemistry and Biochemistry
Committee Member 3
Wujian Miao
Committee Member 3 Department
Chemistry and Biochemistry
Committee Member 4
Vijay Rangachari
Committee Member 4 Department
Chemistry and Biochemistry
Committee Member 5
Matthew Donahue
Committee Member 5 Department
Chemistry and Biochemistry
Abstract
A number of molecular probes have been designed and synthesized for the detection of Zn2+ and Fe3+ ions. Two types of functional groups have been incorporated into the molecular scaffolds to utilize different fluorescent mechanisms. The first class of receptors contains a pyrene moiety. These molecular probes use the excimer mechanism for the detection of Zn2+ ion. The probes work well in an organic solvent with a detection limit of 20 nM (one ppb). Alternatives are made to make them water soluble, but this proved to be difficult. An interesting ion-induced self-assembly system will also be discussed.
The second class of molecules is based on the “Off-On” mechanism. The rhodamine dyes are used in these molecular probes. This system is found to be selective for Fe3+ ions in a mixed organic/aqueous system. A protocol has also been developed to distinguish between Fe3+ and Al3+ ions. One of the rhodamine dyes has also been shown to detect Fe3+ ion in bacteria.
Copyright
Erendra Manandhar, 2014
Recommended Citation
Manandhar, Erendra, "Molecular Probes for the Detection of Zn2+ and Fe3+ Ions" (2014). Dissertations. 43.
https://aquila.usm.edu/dissertations/43