Title

Depression In Medical Students: Gene-Environment Interactions

Document Type

Article

Publication Date

9-1-2010

School

Psychology

Abstract

This study investigated the interaction of genetic, environmental, and psychological factors in predicting depression and anxiety symptoms in medical students. First-year medical students (n = 141) completed measures of anxiety, depression, hope, and spiritual meaning at three time points during the first year. Buccal samples were utilized to genotype each individual at the s/l variant in the promoter region of the serotonin transporter gene (5-HTTLPR). A subset (n = 91) completed a measure of recent stressors. Mean levels of depression increased during year one of medical school. Presence of the s/s genotype in the promoter region of the 5-HTT gene was associated with greater increases in depression, but only in association with higher numbers of recent stressors. Spiritual meaning and hope were found to counteract genetic susceptibility to stress-related depressive symptoms in the more vulnerable s/s group.

Publication Title

Annals of Behavioral Science and Medical Education

Volume

16

First Page

8

Last Page

14

Find in your library

Share

COinS