Title

Gene Selection Using 1-Norm Regularization For Multi-Class Microarray Data

Document Type

Conference Proceeding

Publication Date

12-1-2010

School

Computing Sciences and Computer Engineering

Abstract

Explosive compounds such as TNT and RDX have various toxicological effects on the natural environment. The goal of the earthworm microarray experiment is to unearth the biomarker for toxicity evaluation. We propose a novel recursive gene selection method which can handle the multi-class setting effectively and efficiently. The selection is performed iteratively. In each iteration, a linear multi-class classifier is trained using 1-norm regularization, which leads to sparse weight vectors, i.e., many feature weights are exactly zero. Those zero-weight features are eliminated in the next iteration. The empirical results demonstrate that the selected features (genes) have very competitive discriminative power. In addition, the selection process has fast rate of convergence. ©2010 IEEE.

Publication Title

Proceedings - 2010 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2010

First Page

520

Last Page

524

Find in your library

Share

COinS