A Novel Test Battery To Assess Drug-Induced Changes In Zebrafish Social Behavior
The zebrafish (Danio rerio) has been at the forefront of neurobiological research and is steadily gaining favor as a model organism for behavioral applications. The ease of handling, high yield of progeny, and efficient mode of drug delivery make this species a particularly useful model for behavioral screening. Various drug classes have a range of physiological effects that can impact motor output and social behavior. Using a behavioral paradigm in drug screening can be a useful tool, from determining dose ranges and toxicity to drug-induced behavioral changes. Here we propose a novel behavioral paradigm to assess the group dynamics of zebrafish. This protocol describes methods for simple, fast, and accurate assessment of drug-induced effects on motor and social behavior.
(2011). A Novel Test Battery To Assess Drug-Induced Changes In Zebrafish Social Behavior. Neuromethods, 51, 109-124.
Available at: https://aquila.usm.edu/fac_pubs/20981