Document Type
Article
Publication Date
6-1-2011
Department
Polymers and High Performance Materials
Abstract
Thiolene-based microfluidic devices have been coupled with surface plasmon resonance imaging (SPRI) to provide an integrated platform to study interfacial interactions in both aqueous and organic solutions. In this work, we develop a photolithographic method that interfaces commercially available thiolene resin to gold and glass substrates to generate microfluidic channels with excellent adhesion that leave the underlying sensor surface free from contamination and readily available for surface modification through self-assembly. These devices can sustain high flow rates and have excellent solvent compatibility even with several organic solvents. To demonstrate the versatility of these devices, we have conducted nanomolar detection of streptavidin-biotin interactions using in situ SPRI. (C) 2011 American Institute of Physics. [doi:10.1063/1.3596395]
Publication Title
Biomicrofluidics
Volume
5
Issue
2
Recommended Citation
Sheppard, G.,
Oseki, T.,
Baba, A.,
Patton, D. L.,
Kaneko, F.,
Mao, L.,
Locklin, J.
(2011). Thiolene-Based Microfluidic Flow Cells for Surface Plasmon Resonance Imaging. Biomicrofluidics, 5(2).
Available at: https://aquila.usm.edu/fac_pubs/550
Comments
©Biomicrofluidics
doi.org/10.1063/1.3596395