Peptide-Based Lipid Mimetics With Tunable Core Properties via Thiol-Alkyne Chemistry
Polymers and High Performance Materials
Thiol-alkyne chemistry is utilized to produce peptide-based A2B star polymers. This topography resembles a phospholipid where the polypeptide B block represents a functional, polar head group and the A blocks represent lipophilic units. We utilize a convergent, modular approach to produce lipid mimetics through conjugation of poly(L-glutamic acid) with three different lipophilic moieties (octadecane, cholesterol and polyhedral oligomeric silsesquioxane). All samples are shown to self-assemble in aqueous solution into pH-responsive vesicles. The self-assembly and pH-responsiveness were characterized using circular dichroism spectroscopy and light scattering. Detailed light scattering experiments determined that the aggregation number of the vesicles remains nearly constant as a function of pH, suggesting that the pH-responsiveness is a result of both the helix-coil transition as well as a change in chain packing at the vesicle interface.
Ray, J. G.,
Ly, J. T.,
Savin, D. A.
(2011). Peptide-Based Lipid Mimetics With Tunable Core Properties via Thiol-Alkyne Chemistry. Polymer Chemistry, 2(7), 1536-1541.
Available at: https://aquila.usm.edu/fac_pubs/566