The Drosophila Tumorous Lethal Hematopoietc Oncogene is a Dominant Mutation in Hopscotch Locus
The Drosophila Tumorous-lethal (Tum-l) mutation acts as an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation. Tum-l is a dominant mutation in the hopscotch (hop) locus, which is required for cell division and for proper embryonic segmentation. The Tum-l temperature-sensitive period for melanotic tumor formation includes most of larval and pupal development.
Molecular and General Genetics
Hanratty, W. P.,
Dearolf, C. R.
(1993). The Drosophila Tumorous Lethal Hematopoietc Oncogene is a Dominant Mutation in Hopscotch Locus. Molecular and General Genetics, 238(41276), 33-37.
Available at: https://aquila.usm.edu/fac_pubs/8743