Date of Award
Honors College Thesis
Chemistry and Biochemistry
Karl Wallace, Ph.D.
A class of compounds called “legal highs” is known to be psychoactive. These substances provide the user with a psychoactive experience or a “high.” They are not currently illegal by any governing body. The aim of this study was to design and synthesize molecular probes to target “legal highs”. Upon binding, a color change or fluorescence change can occur, which would imply that the drug is present. Psychoactive drugs generally contain an amine functional group. The sensors synthesized in this project bind to the amine functional group, which result in a spectroscopic response. Structural elucidation was carried out by Proton Nuclear Magnetic Resonance (1H-NMR). Additionally, UV-Vis spectroscopy was utilized to determine any colorimetric change. This study contributes to the field of drug recognition and molecular design.
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Roberts, Hannah C., "Synthesis of a Colorimetric Probe for Psychoactive Drugs" (2015). Honors Theses. 460.