Date of Award
Master of Arts (MA)
Committee Chair Department
Committee Member 2
Committee Member 2 Department
Educational Studies and Research
Committee Member 3
Committee Member 3 Department
Addiction and substance abuse commonly lead to negative outcomes such damaged health, domestic violence, child abuse, failure in school, and loss of employment. In the United States, hundreds of billions of dollars accrue annually in costs associated with healthcare, crime and lost productivity due to addiction. Efficacious treatments remain few in number, the development of which will be facilitated by comprehension of environmental, genetic, pharmacological and neurobiological mechanisms implicated in the pathogenesis of addiction. The zebrafish (Danio rerio) has recently gained popularity as a model organism of complex brain disorders (e.g., substance use disorder). Behavioral quantification within the conditioned place preference (CPP) paradigm serves as a measure of the rewarding qualities of a given stimulus (e.g., drug). If animals develop an increase in preference to spend time in an environment that had previously been paired with drug administration, the drug is inferred to have rewarding properties. This project reports the effects of acute (1 day) and chronic (7 days) exposure to alcohol, caffeine and nicotine on zebrafish CPP behavior.
Doctoral dissertation: http://aquila.usm.edu/dissertations/1388/
2015, Adam Douglas Collier
Collier, Adam Douglas, "Zebrafish and Conditioned Place Preference: A Translational Model of Drug Reward" (2015). Master's Theses. 132.