Date of Award

5-2012

Degree Type

Masters Thesis

Degree Name

Master of Science (MS)

Department

Chemistry and Biochemistry

Committee Chair

Douglas Masterson

Committee Chair Department

Chemistry and Biochemistry

Abstract

Modification of cysteine containing peptides by the thiol group of cysteine with radical precursors allows a simple and localized generation of radical species in the collision cell of mass spectrometer. The proof of principle and the analysis of the radical derived fragments of a set of different model peptides are described further in the manuscript as well as the importance and potential applications of the method.

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