Date of Award

Summer 8-2015

Degree Type

Masters Thesis

Degree Name

Master of Science (MS)

Department

Chemistry and Biochemistry

Committee Chair

Dr. Anthony J. Bell Jr.

Committee Chair Department

Chemistry and Biochemistry

Committee Member 2

Dr. Philip D. Bates

Committee Member 2 Department

Chemistry and Biochemistry

Committee Member 3

Dr. Robert C. Bateman

Abstract

The objective is to evaluate the ability of aminoacyl-tRNA synthetases (aaRS) to recognize the non-standard nucleic acid, PNA (peptide nucleic acid). PNA has immense potential in biomedical applications due to its increased thermostability and nuclease resistance over natural nucleic acids. PNA represents a superior alternative to natural nucleic acids in many biomedical applications due to its specificity, strong binding, and nuclease resistance. This study is the initial data set that indicates PNA are recognized by translation enzymes.

Included in

Biochemistry Commons

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