Highly Potent Anti-Proliferative Effects of a Gallium (III) Complex With 7-Chloroquinoline Thiosemicarbazone as a Ligand: Synthesis, Cytotoxic and Antimalarial Evaluation
Document Type
Article
Publication Date
10-30-2014
Department
Biological Sciences
School
Biological, Environmental, and Earth Sciences
Abstract
A gallium(III) complex with 7-chloroquinoline thiosemicarbazone was synthesized and characterized. The complex proved to be thirty-one times more potent on colon cancer cell line, HCT-116, with considerably less cytotoxicity on non-cancerous colon fibroblast, CCD-18Co, when compared to etoposide. Its anti-malarial potential on 3D7 isolate of Plasmodium falciparum was better than lumefantrine.
Publication Title
European Journal of Medicinal Chemistry
Volume
86
First Page
81
Last Page
86
Recommended Citation
Kumar, K.,
Schniper, S.,
González-Sarrías, A.,
Holder, A. A.,
Sanders, N.,
Sullivan, D.,
Jarrett, W. L.,
Davis, K.,
Bai, F.,
Seeram, N. P.,
Kumar, V.
(2014). Highly Potent Anti-Proliferative Effects of a Gallium (III) Complex With 7-Chloroquinoline Thiosemicarbazone as a Ligand: Synthesis, Cytotoxic and Antimalarial Evaluation. European Journal of Medicinal Chemistry, 86, 81-86.
Available at: https://aquila.usm.edu/fac_pubs/15124
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