Pro-Antimicrobial Networks via Degradable Acetals (PANDAs) Using Thiol-Ene Photopolymerization

Authors

Dahlia N. Amato, University of Southern MississippiFollow
Douglas V. Amato, University of Southern MississippiFollow
Olga V. Mavrodi, University of Southern MississippiFollow
William B. Martin, University of Southern MississippiFollow
Sarah N. Swilley, University of Southern MississippiFollow
Keith H. Parsons, University of Southern MississippiFollow
Dmitri V. Mavrodi, University of Southern MississippiFollow
Derek L. Patton, University of Southern MississippiFollow

Document Type

Article

Publication Date

2-6-2017

Department

Biological Sciences

School

Biological, Environmental, and Earth Sciences

Abstract

We describe the synthesis of pro-antimicrobial networks via degradable acetals (PANDAs) as a new paradigm for sequestration and triggered release of volatile, bioactive aldehydes. PANDAs derived from diallyl p-chlorobenzaldehyde acetal degrade and release p-chlorobenzaldehyde as an antibacterial and antifungal agent under mild conditions (pH 7.4/high humidity). We show that PANDAs enable facile access to materials with tunable release profiles, potent antimicrobial activity without triggering antimicrobial resistance, and minimal cytotoxicity.

Publication Title

ACS Macro Letters

Volume

6

Issue

2

First Page

171

Last Page

175

Recommended Citation

Amato, D. N., Amato, D. V., Mavrodi, O. V., Martin, W. B., Swilley, S. N., Parsons, K. H., Mavrodi, D. V., Patton, D. L. (2017). Pro-Antimicrobial Networks via Degradable Acetals (PANDAs) Using Thiol-Ene Photopolymerization. ACS Macro Letters, 6(2), 171-175.
Available at: https://aquila.usm.edu/fac_pubs/15176