Aqueous RAFT at pH Zero: Enabling Controlled Polymerization of Unprotected Acyl Hydrazide Methacrylamides
Polymers and High Performance Materials
We report aqueous RAFT polymerization at pH = 0 mediated by a novel imidazolium-containing chain transfer agent. In 1 M HCl, unprecedented controlled polymerization and chain-extension of unprotected acyl hydrazide methacrylamides is achieved enabling the synthesis of well-defined acyl hydrazide functionalized polymer scaffolds of interest for dynamic covalent and bioconjugation strategies.
Hoff, E. A.,
Abel, B. A.,
McCormick, C. L.,
Patton, D. L.
(2017). Aqueous RAFT at pH Zero: Enabling Controlled Polymerization of Unprotected Acyl Hydrazide Methacrylamides. Polymer Chemistry, 8(34), 4978-4982.
Available at: https://aquila.usm.edu/fac_pubs/15184