An Activated Coumarin-Enamine Michael Acceptor for CN-
Chemistry and Biochemistry
Two coumarin-enamine chemodosimeters have been synthesized in three steps. They have been shown to selectively detect the cyanide ion with a fluorescent response (t1/2 = 20 s) and a limit of detection approximately 4.2 ppb in DMSO. The X-ray crystal structure of the thermodynamically stable E-(keto) enamine isomer of one compound was obtained and exhibited offset π-stacking.
New Journal of Chemistry
Davis, A. B.,
Lambert, R. E.,
Fronczek, F. R.,
Cragg, P. J.,
Wallace, K. J.
(2014). An Activated Coumarin-Enamine Michael Acceptor for CN-. New Journal of Chemistry, 38, 4678-4683.
Available at: https://aquila.usm.edu/fac_pubs/15207