Mechanical Contraction to Guide CRT Left-Ventricular Lead Placement Instead of Electrical Activation in Myocardial Infarction With Left Ventricular Dysfunction: An Experimental Study Based On Non-Invasive Gated Myocardial Perfusion Imaging and Invasive Electroanatomic Mapping

Authors

Jianfeng Wang, The Third Affiliated Hospital of Soochow UniversityFollow
Yuetao Wang, The Third Affiliated Hospital of Soochow UniversityFollow
Minfu Yang
Shan Shao, Capital Medical University
Yi Tian, Capital Medical University
Xiaoliang Shao, The Third Affiliated Hospital of Soochow University
Shengdeng Fan, The Third Affiliated Hospital of Soochow University
Feifei Zhang, The Third Affiliated Hospital of Soochow UniversityFollow
Wei Yang, The Third Affiliated Hospital of Soochow UniversityFollow
Wenchong Xin, The Third Affiliated Hospital of Soochow University
Haipeng Tang, University of Southern MississippiFollow
Min Xu, The Third Affiliated Hospital of Soochow University
Ling Yang, The Third Affiliated Hospital of Soochow UniversityFollow
Xiaosong Wang, The Third Affiliated Hospital of Soochow University
Weihua Zhou, University of Southern MississippiFollow

Document Type

Article

Publication Date

4-9-2019

Department

Computing

School

Computing Sciences and Computer Engineering

Abstract

Background: Whether the region of the latest electrical activation (LEA) corresponds with the segment of the latest mechanical contraction (LMC) in ischemic cardiomyopathy (ICM) is uncertain. We aimed to investigate the relationship between the left-ventricular (LV) viable segments with LEA and with LMC after myocardial infarction (MI) and analyze the acute hemodynamic responses (dP/dt_max) after cardiac resynchronization therapy (CRT) pacing at different LV sites.

Methods and results: Bama suckling pigs (n = 6) were subjected to create MI models. Both gated myocardial perfusion imaging (GMPI) and electroanatomic mapping (EAM) were performed successfully before MI and 4 weeks after MI. LMC was assessed by phase analysis of GMPI, while LEA was evaluated by EAM. The dP/dt_max was measured before CRT and when the CRT LV electrode was implanted in viable segments of LMC, viable segments of lateral wall and scar, respectively. The viable segments of LEA were consistent with the sites of LMC for five in six cases. The dP/dt_max increased significantly compared with that before CRT when the CRT LV electrode was implanted in viable segments of LMC (1103.33 ± 195.76 vs 717.83 ± 80.74 mmHg·s⁻¹, P = .001), which was also significantly higher than in viable segments of lateral wall (751.17 ± 105.62 mmHg·s⁻¹, P = .000) and scar (679.50 ± 60.87 mmHg·s⁻¹, P = .001).

Conclusions: Non-invasive GMPI may be a better option than invasive EAM for guiding LV electrode implantation for CRT in ICM.

Publication Title

Journal of Nuclear Cardiology

Recommended Citation

Wang, J., Wang, Y., Yang, M., Shao, S., Tian, Y., Shao, X., Fan, S., Zhang, F., Yang, W., Xin, W., Tang, H., Xu, M., Yang, L., Wang, X., Zhou, W. (2019). Mechanical Contraction to Guide CRT Left-Ventricular Lead Placement Instead of Electrical Activation in Myocardial Infarction With Left Ventricular Dysfunction: An Experimental Study Based On Non-Invasive Gated Myocardial Perfusion Imaging and Invasive Electroanatomic Mapping. Journal of Nuclear Cardiology.
Available at: https://aquila.usm.edu/fac_pubs/16141