A New Strategy for the In Vitro Selection of Stapled Peptide Inhibitors by mRNA Display
Document Type
Article
Publication Date
7-10-2019
Department
Chemistry and Biochemistry
School
Mathematics and Natural Sciences
Abstract
Hydrocarbon stapled peptides are promising therapeutics for inhibition of intracellular protein–protein interactions. Here we develop a new high-throughput strategy for hydrocarbon stapled peptide discovery based on mRNA display of peptides containing α-methyl cysteine and cyclized with m-dibromoxylene. We focus on development of a peptide binder to the HPV16 E2 protein.
Publication Title
Chemical Communications
Volume
55
First Page
8959
Last Page
8962
Recommended Citation
Iqbal, E. S.,
Richardson, S. L.,
Abrigo, N. A.,
Dods, K. K.,
Franco, H. O.,
Gerrish, H. S.,
Kotapati, H. K.,
Morgan, I. M.,
Masterson, D. S.,
Hartman, M. C.
(2019). A New Strategy for the In Vitro Selection of Stapled Peptide Inhibitors by mRNA Display. Chemical Communications, 55, 8959-8962.
Available at: https://aquila.usm.edu/fac_pubs/16481