Title

A New Strategy for the In Vitro Selection of Stapled Peptide Inhibitors by mRNA Display

Document Type

Article

Publication Date

7-10-2019

Department

Chemistry and Biochemistry

Abstract

Hydrocarbon stapled peptides are promising therapeutics for inhibition of intracellular protein–protein interactions. Here we develop a new high-throughput strategy for hydrocarbon stapled peptide discovery based on mRNA display of peptides containing α-methyl cysteine and cyclized with m-dibromoxylene. We focus on development of a peptide binder to the HPV16 E2 protein.

Publication Title

Chemical Communications

Volume

55

First Page

8959

Last Page

8962

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