A Novel Copper(II) Complex Identified as a Potent Drug Against Colorectal and Breast Cancer Cells and as a Poison Inhibitor for Human Topoisomerase II alpha

Authors

Shayna Sandhaus, Florida International University
Rosella Taylor, University of Southern Mississippi
Tiffany Edwards, University of Southern Mississippi
Alexis Huddleston, University of Southern Mississippi
Ykeysha Wooten, University of Southern Mississippi
Ramaiyer Venkatraman, Jackson State University
Ralph T. Weber, Bruker BioSpinFollow
Antonio Gonzalez-Sarrias, University of Rhode Island
Patrick M. Martin, North Carolina Agricultural and Technical State University
Patrice Cagle, North Carolina Agricultural and Technical State University
Yuk-Ching Tse-Dinh, Florida International University
Stephen J. Beebe, Old Dominion University
Navindra Seeram, University of Rhode IslandFollow
Alvin A. Holder, Old Dominion UniversityFollow

Document Type

Article

Publication Date

2-2016

Department

Chemistry and Biochemistry

Abstract

A novel complex, [Cu(acetylethTSC)Cl]Cl·0.25C₂H₅OH 1 (where acetylethTSC = (E)-N-ethyl-2-[1-(thiazol-2-yl)ethylidene]hydrazinecarbothioamide), was shown to have anti-proliferative activity against various colon and aggressive breast cancer cell lines. In vitro studies showed that complex 1 acted as a poison inhibitor of human topoisomerase IIα, which may account for the observed anti-cancer effects. (C) 2015 Elsevier B.V. All rights reserved.

Publication Title

Inorganic Chemistry Communications

Volume

64

First Page

45

Last Page

49

Recommended Citation

Sandhaus, S., Taylor, R., Edwards, T., Huddleston, A., Wooten, Y., Venkatraman, R., Weber, R. T., Gonzalez-Sarrias, A., Martin, P. M., Cagle, P., Tse-Dinh, Y., Beebe, S. J., Seeram, N., Holder, A. A. (2016). A Novel Copper(II) Complex Identified as a Potent Drug Against Colorectal and Breast Cancer Cells and as a Poison Inhibitor for Human Topoisomerase II alpha. Inorganic Chemistry Communications, 64, 45-49.
Available at: https://aquila.usm.edu/fac_pubs/17525