A Novel Copper(II) Complex Identified as a Potent Drug Against Colorectal and Breast Cancer Cells and as a Poison Inhibitor for Human Topoisomerase II alpha

Document Type

Article

Publication Date

2-2016

Department

Chemistry and Biochemistry

Abstract

A novel complex, [Cu(acetylethTSC)Cl]Cl·0.25C2H5OH 1 (where acetylethTSC = (E)-N-ethyl-2-[1-(thiazol-2-yl)ethylidene]hydrazinecarbothioamide), was shown to have anti-proliferative activity against various colon and aggressive breast cancer cell lines. In vitro studies showed that complex 1 acted as a poison inhibitor of human topoisomerase IIα, which may account for the observed anti-cancer effects. (C) 2015 Elsevier B.V. All rights reserved.

Publication Title

Inorganic Chemistry Communications

Volume

64

First Page

45

Last Page

49

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