A Novel Copper(II) Complex Identified as a Potent Drug Against Colorectal and Breast Cancer Cells and as a Poison Inhibitor for Human Topoisomerase II alpha
Chemistry and Biochemistry
A novel complex, [Cu(acetylethTSC)Cl]Cl·0.25C2H5OH 1 (where acetylethTSC = (E)-N-ethyl-2-[1-(thiazol-2-yl)ethylidene]hydrazinecarbothioamide), was shown to have anti-proliferative activity against various colon and aggressive breast cancer cell lines. In vitro studies showed that complex 1 acted as a poison inhibitor of human topoisomerase IIα, which may account for the observed anti-cancer effects. (C) 2015 Elsevier B.V. All rights reserved.
Inorganic Chemistry Communications
Weber, R. T.,
Martin, P. M.,
Beebe, S. J.,
Holder, A. A.
(2016). A Novel Copper(II) Complex Identified as a Potent Drug Against Colorectal and Breast Cancer Cells and as a Poison Inhibitor for Human Topoisomerase II alpha. Inorganic Chemistry Communications, 64, 45-49.
Available at: https://aquila.usm.edu/fac_pubs/17525