Document Type
Article
Publication Date
3-2016
Department
Biological Sciences
School
Biological, Environmental, and Earth Sciences
Abstract
Tick saliva facilitates tick feeding and infection of the host. Gene expression analysis of tick salivary glands and other tissues involved in host-pathogen interactions has revealed a wide range of bioactive tick proteins. Transcriptomic analysis has been a milestone in the field and has recently been enhanced by next-generation sequencing (NGS). Furthermore, the application of quantitative proteomics to ticks with unknown genomes has provided deeper insights into the molecular mechanisms underlying tick hematophagy, pathogen transmission, and tick-host-pathogen interactions. We review current knowledge on the transcriptomics and proteomics of tick tissues from a systems-biology perspective and discuss future challenges in the field.
Publication Title
Trends in Parasitology
Volume
32
Issue
3
First Page
242
Last Page
254
Recommended Citation
Chmelar, J.,
Kotal, J.,
Karim, S.,
Kopacek, P.,
Francischetti, I. M.,
Pedra, J. H.,
Kotsyfakis, M.
(2016). Sialomes and Mialomes: A Systems-Biology View of Tick Tissues and Tick-Host Interactions. Trends in Parasitology, 32(3), 242-254.
Available at: https://aquila.usm.edu/fac_pubs/17537
Comments
Accepted version available through a CC BY-NC-ND license. The final, published version is available from the publisher's website: https://doi.org/10.1016/j.pt.2015.10.002