Document Type
Article
Publication Date
12-1-2020
Department
Biological Sciences
School
Biological, Environmental, and Earth Sciences
Abstract
The msaABCR operon regulates several staphylococcal phenotypes such as biofilm formation, capsule production, protease production, pigmentation, antibiotic resistance, and persister cells formation. The msaABCR operon is required for maintaining the cell wall integrity via affecting peptidoglycan cross-linking. The msaABCR operon also plays a role in oxidative stress defense mechanism, which is required to facilitate persistent and recurrent staphylococcal infections. Staphylococcus aureus is the most frequent cause of chronic implant-associated osteomyelitis (OM). The CA-MRSA USA300 strains are predominant in the United States and cause severe infections, including bone and joint infections.
Publication Title
BMC Microbiology
Volume
20
Issue
1
First Page
1
Last Page
20
Recommended Citation
Sahukhal, G.,
Tucci, M.,
Benghuzzi, H.,
Wilson, G.,
Elasri, M.
(2020). The Role of the msaABCR Operon In Implant-Associated Chronic Osteomyelitis in Staphylococcus aureus USA300 LAC. BMC Microbiology, 20(1), 1-20.
Available at: https://aquila.usm.edu/fac_pubs/18187