Document Type

Article

Publication Date

8-1-2015

Abstract

Background: Monitoring central hemodynamic responses to an orthostatic challenge may provide important insight into autonomic nervous system function. Oscillometric pulse wave analysis devices have recently emerged, presenting clinically viable options for investigating central hemodynamic properties. The purpose of the current study was to determine whether oscillometric pulse wave analysis can be used to reliably (between-day) assess central blood pressure and central pressure augmentation (augmentation index) responses to a 5 min orthostatic challenge (modified tilt-table).

Methods: Twenty healthy adults (26.4 y (SD 5.2), 55% F, 24.7 kg/m2 (SD 3.8)) were tested on 3 different mornings in the fasted state, separated by a maximum of 7 days. Central hemodynamic variables were assessed on the left arm using an oscillometric device.

Results: Repeated measures analysis of variance indicated a significant main effect of the modified tilt-table for all central hemodynamic variables (P < 0.001). In response to the tilt, central diastolic pressure increased by 4.5 mmHg (CI: 2.6, 6.4), central systolic blood pressure increased by 2.3 (CI: 4.4, 0.16) mmHg, and augmentation index decreased by an absolute – 5.3%, (CI: −2.7, −7.9%). The intra-class correlation coefficient values for central diastolic pressure (0.83–0.86), central systolic blood pressure (0.80–0.87) and AIx (0.79–0.82) were above the 0.75 criterion in both the supine and tilted positions, indicating excellent between-day reliability.

Conclusion: Central hemodynamic responses to an orthostatic challenge can be assessed with acceptable between-day reliability using oscillometric pulse wave analysis.

Comments

© This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/.

Publication Title

Atherosclerosis

Volume

241

Issue

2

First Page

761

Last Page

765

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