Document Type
Article
Publication Date
12-1-2020
Department
Biological Sciences
School
Biological, Environmental, and Earth Sciences
Abstract
Osteopontin (OPN), a multifunctional protein encoded by the secreted phosphoprotein-1 (Spp-1) gene in humans, plays important roles in a variety of physiological conditions, such as biomineralization, bone remodeling and immune functions. OPN also has significant roles in the pathogenesis of autoimmune, allergy and inflammatory diseases, as well as bacterial, fungal and viral infections. West Nile virus (WNV), a mosquito-transmitted flavivirus, is the leading agent for viral encephalitis in North America. Recent progress has been made in understanding both the biological functions of OPN and the pathogenesis of WNV. In this review article, we have summarized the current understanding of the biology of OPN and its vital roles in the pathogenesis of WNV encephalitis.
Publication Title
Vaccines
Volume
8
Issue
4
First Page
1
Last Page
12
Recommended Citation
Nazneen, F.,
Bai, F.
(2020). The Roles of Osteopontin In the Pathogenesis of West Nile Encephalitis. Vaccines, 8(4), 1-12.
Available at: https://aquila.usm.edu/fac_pubs/19063