Smuggle Tau Through a Secret(ory) Pathway
Document Type
Article
Publication Date
7-1-2021
Department
Biological Sciences
School
Biological, Environmental, and Earth Sciences
Abstract
Secretion of misfolded tau, a microtubule-binding protein enriched in nerve cells, is linked to the progression of tau pathology. However, the molecular mechanisms underlying tau secretion are poorly understood. Recent work by Lee et al. [Biochemical J. (2021) 478: 1471-1484] demonstrated that the transmembrane domains of syntaxin6 and syntaxin8 could be exploited for tau release, setting a stage for testing a novel hypothesis that has profound implications in tauopathies (e.g. Alzheimer's disease, FTDP-17, and CBD/PSP) and other related neurodegenerative diseases. The present commentary highlights the importance and limitations of the study, and discusses opportunities and directions for future investigations.
Publication Title
Biochemical Journal
Volume
478
Issue
14
First Page
2921
Last Page
2925
Recommended Citation
Xu, H.
(2021). Smuggle Tau Through a Secret(ory) Pathway. Biochemical Journal, 478(14), 2921-2925.
Available at: https://aquila.usm.edu/fac_pubs/19235