Document Type
Article
Publication Date
7-14-2014
Abstract
Iron porphyrin carbenes (IPCs) are thought to be intermediates involved in the metabolism of various xenobiotics by cytochrome P450, as well as in chemical reactions catalyzed by metalloporphyrins and engineered P450s. While early work proposed IPCs to contain FeII, more recent work invokes a double-bond description of the iron–carbon bond, similar to that found in FeIV porphyrin oxenes. Reported herein is the first quantum chemical investigation of IPC Mössbauer and NMR spectroscopic properties, as well as their electronic structures, together with comparisons to ferrous heme proteins and an FeIV oxene model. The results provide the first accurate predictions of the experimental spectroscopic observables as well as the first theoretical explanation of their electrophilic nature, as deduced from experiment. The preferred resonance structure is FeII←{:C(X)Y}0 and not FeIV{C(X)Y}2−, a result that will facilitate research on IPC reactivities in various chemical and biochemical systems.
Publication Title
Angewandte Chemie - International Edition
Volume
53
Issue
29
First Page
7574
Last Page
7578
Recommended Citation
Khade, R.,
Fan, W.,
Ling, Y.,
Yang, L.,
Oldfield, E.,
Zhang, Y.
(2014). Iron Porphyrin Carbenes As Catalytic Intermediates: Structures, Mössbauer and NMR Spectroscopic Properties, and Bonding. Angewandte Chemie - International Edition, 53(29), 7574-7578.
Available at: https://aquila.usm.edu/fac_pubs/19907
Comments
This is the peer reviewed version of the following article: [Iron Porphyrin Carbenes as Catalytic Intermediates: Structures, Mössbauer and NMR Spectroscopic Properties, and Bonding. Angewandte Chemie International Edition 53, 29 p7574-7578 (2014)], which has been published in final form at https://doi.org/10.1002/anie.201402472. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions: https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html#3.