Breast Cancer Survivors' Typhoid Vaccine Responses: Chemotherapy, Obesity, and Fitness Make a Difference

Authors

Janice K. Kiecolt-Glaser, Ohio State UniversityFollow
Megan Renna, University of Southern MississippiFollow
Juan Peng, Ohio State University
John Sheridan, Ohio State University
Maryam Lustberg, Yale School of MedicineFollow
Bhuvaneswari Ramaswamy, Ohio State UniversityFollow
Robert Wesolowski, Ohio State University
Jeffrey B. VanDeusen, Ohio State University
Nicole O. Williams, Ohio State UniversityFollow
Sagar D. Sardesai, Ohio State UniversityFollow
Anne M. Noonan, Ohio State UniversityFollow
Raquel E. Reinbolt, Ohio State University
Daniel G. Stover, Ohio State UniversityFollow
Mathew A. Cherian, Ohio State UniversityFollow
William B. Malarkey, Ohio State UniversityFollow
Rebecca Andridge, Ohio State UniversityFollow

Document Type

Article

Publication Date

7-1-2022

School

Psychology

Abstract

Purpose: To investigate breast cancer survivors’ inflammatory responses to typhoid vaccine as a window into their innate immune response to novel pathogens.

Methods: This double-blind crossover trial randomized 158 breast cancer survivors to either the vaccine/saline placebo or the placebo/vaccine sequence. The relative contributions of age, cardiorespiratory fitness (VO_2peak), type of cancer treatment, central obesity, and depression to interleukin (IL)-6, IL-1 receptor antagonist (IL-1Ra), and WBC vaccine responses were assessed pre-injection and 1.5, 3, 4.5, 6, and 7.5 h post-injection.

Results: The vaccine produced larger IL-6, IL-1Ra, and WBC responses than placebo, ps < 0.0001. Prior chemotherapy, higher central obesity, and lower VO_2peak were associated with smaller vaccine responses after controlling for baseline inflammation. Vaccine response was summarized by the percent increase in area under the curve (IL-6, WBC) or average post-injection mean (IL-1Ra) for vaccine relative to placebo. Women who received chemotherapy had smaller vaccine responses than women who did not for both IL-6 (44% vs 78%, p 2peak had smaller vaccine responses than women whose VO_2peakwas one standard deviation above the mean for IL-6 (54% vs 73%, p

Conclusions: This study provided novel data on chemotherapy’s longer-term adverse immune consequences. The data also have an important public health message: even relatively low levels of fitness can benefit the innate immune response to a vaccine.

Publication Title

Brain, Behavior, and Immunity

Volume

103

First Page

1

Last Page

9

Recommended Citation

Kiecolt-Glaser, J. K., Renna, M., Peng, J., Sheridan, J., Lustberg, M., Ramaswamy, B., Wesolowski, R., VanDeusen, J. B., Williams, N. O., Sardesai, S. D., Noonan, A. M., Reinbolt, R. E., Stover, D. G., Cherian, M. A., Malarkey, W. B., Andridge, R. (2022). Breast Cancer Survivors' Typhoid Vaccine Responses: Chemotherapy, Obesity, and Fitness Make a Difference. Brain, Behavior, and Immunity, 103, 1-9.
Available at: https://aquila.usm.edu/fac_pubs/20462