Killing Two Birds With One Stone: Phosphorylation By a Tabun Mimic and Subsequent Capture of Cyanide Using a Single Fluorescent Chemodosimeter

Authors

Rashid Mia, University of Southern MississippiFollow
Peter J. Cragg, University of BrightonFollow
Frank R. Fronczek, Louisiana State UniversityFollow
Karl J. Wallace, University of Southern MississippiFollow

Document Type

Article

Publication Date

10-24-2022

Department

Chemistry and Biochemistry

School

Mathematics and Natural Sciences

Abstract

In the presence of the tabun mimic diethylcyanophosphonate (DECP), a fluorescent bifunctional coumarin–enamine chemodosimeter is first phosphorylated and subsequently attacked by the released cyanide ions. The reaction is disclosed in both the UV-vis and fluorescence spectra and confirmed by NMR experiments. DFT calculations support that the bis-adduct as the most thermodynamically stable species. The X-ray structure of the chemodosimeter is also reported.

Publication Title

New Journal of Chemistry

Volume

46

First Page

21278

Last Page

21286

Recommended Citation

Mia, R., Cragg, P. J., Fronczek, F. R., Wallace, K. J. (2022). Killing Two Birds With One Stone: Phosphorylation By a Tabun Mimic and Subsequent Capture of Cyanide Using a Single Fluorescent Chemodosimeter. New Journal of Chemistry, 46, 21278-21286.
Available at: https://aquila.usm.edu/fac_pubs/20572